/* ===== 肝癌抗血管+免疫 文献集 · 零依赖样式 ===== */
:root{
  --bg:#f5f8f8; --surface:#ffffff; --surface-2:#eef3f4; --surface-3:#e6eeef;
  --text:#152a30; --muted:#5d7178; --faint:#85979d;
  --border:#dce6e8; --border-2:#cbd9db;
  --brand:#0e7c86; --brand-2:#0a5d66; --brand-soft:#d6ecee;
  --core:#c2410c; --core-soft:#fbe6da;
  --link:#0a6c75;
  --shadow:0 1px 2px rgba(16,40,46,.05), 0 6px 24px -12px rgba(16,40,46,.18);
  --radius:14px;
  --maxw:1080px;
}
@media (prefers-color-scheme: dark){
  :root{
    --bg:#0b1416; --surface:#101c20; --surface-2:#16262b; --surface-3:#1c3036;
    --text:#e7eff0; --muted:#a4b7bc; --faint:#7d9197;
    --border:#1f343a; --border-2:#284249;
    --brand:#2dd4bf; --brand-2:#5eead4; --brand-soft:#10312f;
    --core:#fb923c; --core-soft:#3a2310;
    --link:#5eead4;
    --shadow:0 1px 2px rgba(0,0,0,.3), 0 8px 30px -14px rgba(0,0,0,.6);
  }
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  margin:0; background:var(--bg); color:var(--text);
  font-family:-apple-system,BlinkMacSystemFont,"Segoe UI","Noto Sans SC","PingFang SC","Microsoft YaHei",Roboto,Helvetica,Arial,sans-serif;
  line-height:1.65; -webkit-font-smoothing:antialiased; text-rendering:optimizeLegibility;
}
.wrap{max-width:var(--maxw); margin:0 auto; padding:0 22px}

/* ===== Hero ===== */
.hero{
  position:relative; overflow:hidden; color:#eafafa;
  background:
    radial-gradient(1100px 380px at 82% -40%, rgba(45,212,191,.30), transparent 60%),
    radial-gradient(800px 300px at 5% 120%, rgba(194,65,12,.22), transparent 55%),
    linear-gradient(135deg,#0a4750 0%,#0c5a63 42%,#0a4f57 100%);
  padding:62px 0 46px;
  border-bottom:1px solid rgba(255,255,255,.08);
}
.hero::after{content:"";position:absolute;inset:0;
  background:linear-gradient(180deg,transparent 60%,rgba(0,0,0,.18));pointer-events:none}
.hero .wrap{position:relative;z-index:1}
.eyebrow{font-size:13px;letter-spacing:.22em;text-transform:uppercase;color:#7fe9dc;font-weight:600;margin-bottom:14px}
.hero h1{font-size:clamp(30px,5.2vw,52px);line-height:1.08;margin:0 0 12px;font-weight:800;letter-spacing:-.5px}
.hero h1 .amp{font-weight:400;opacity:.7;margin:0 .12em;font-size:.7em;vertical-align:.06em}
.hero .sub{margin:0 0 22px;font-size:clamp(14px,2vw,18px);color:#bfeae6;font-weight:400;letter-spacing:.02em}
.meta-row{display:flex;flex-wrap:wrap;gap:10px}
.chip{
  display:inline-flex;align-items:center;gap:6px;
  background:rgba(255,255,255,.12);border:1px solid rgba(255,255,255,.18);
  color:#eafafa;border-radius:999px;padding:6px 14px;font-size:13.5px;font-weight:500;
  backdrop-filter:blur(4px);
}
.chip-key{background:rgba(255,255,255,.2);font-weight:600}

/* ===== Cards / sections ===== */
main{padding:34px 0 60px}
.card{
  background:var(--surface);border:1px solid var(--border);border-radius:var(--radius);
  box-shadow:var(--shadow);padding:26px 28px;
}
.section-title{font-size:20px;margin:0 0 16px;font-weight:750;letter-spacing:-.2px;display:flex;align-items:baseline;gap:10px}
.section-title .en{font-size:13px;font-weight:500;color:var(--faint);letter-spacing:.04em}
.overview{margin-bottom:30px}
.overview-body p{margin:0 0 14px;color:var(--text);font-size:15.5px}
.overview-body p:last-child{margin-bottom:0}
.overview-body strong{color:var(--brand-2);font-weight:700}
@media (prefers-color-scheme: dark){.overview-body strong{color:var(--brand-2)}}

/* ===== Timeline ===== */
.timeline{list-style:none;display:flex;gap:0;margin:24px 0 4px;padding:14px 2px 4px;overflow-x:auto;counter-reset:tl}
.timeline li{position:relative;flex:1 0 132px;min-width:132px;padding:0 14px;border-top:2px solid var(--border-2)}
.timeline li::before{content:"";position:absolute;top:-7px;left:14px;width:12px;height:12px;border-radius:50%;background:var(--brand);box-shadow:0 0 0 4px var(--surface)}
.timeline li.core::before{background:var(--core)}
.timeline .yr{display:block;font-weight:800;font-size:15px;margin-top:14px;color:var(--text)}
.timeline .ev{display:block;font-size:12.5px;color:var(--muted);margin-top:2px;line-height:1.4}

/* ===== Controls ===== */
.controls{margin:0 0 22px;position:sticky;top:0;z-index:20;
  background:linear-gradient(var(--bg) 70%,transparent);padding-top:10px;backdrop-filter:blur(2px)}
.search-wrap{position:relative;display:flex;align-items:center}
.search-ico{position:absolute;left:15px;width:19px;height:19px;fill:none;stroke:var(--faint);stroke-width:2;stroke-linecap:round}
#search{
  width:100%;padding:14px 44px 14px 44px;border:1px solid var(--border);border-radius:12px;
  background:var(--surface);color:var(--text);font-size:15.5px;box-shadow:var(--shadow);
}
#search:focus{outline:none;border-color:var(--brand);box-shadow:0 0 0 3px var(--brand-soft)}
.clear-btn{position:absolute;right:8px;border:none;background:transparent;color:var(--faint);
  font-size:22px;cursor:pointer;width:34px;height:34px;border-radius:8px;line-height:1;display:none}
.clear-btn:hover{background:var(--surface-2);color:var(--text)}
.clear-btn.show{display:block}
.filter-row{display:flex;align-items:center;justify-content:space-between;gap:14px;margin-top:14px;flex-wrap:wrap}
.chips{display:flex;flex-wrap:wrap;gap:8px}
.fchip{
  border:1px solid var(--border-2);background:var(--surface);color:var(--muted);
  border-radius:999px;padding:6px 13px;font-size:13px;font-weight:600;cursor:pointer;
  transition:all .12s ease;display:inline-flex;align-items:center;gap:7px;white-space:nowrap;
}
.fchip:hover{border-color:var(--ccolor,var(--brand));color:var(--text)}
.fchip .dot{width:9px;height:9px;border-radius:50%;background:var(--ccolor,var(--brand));flex:none}
.fchip .n{font-weight:700;color:var(--faint);font-size:12px}
.fchip.active{background:var(--ccolor,var(--brand));border-color:var(--ccolor,var(--brand));color:#fff}
.fchip.active .dot{background:#fff}
.fchip.active .n{color:rgba(255,255,255,.85)}
.fchip.all{--ccolor:var(--brand)}
.control-right{display:flex;align-items:center;gap:10px}
.sort-label{font-size:13px;color:var(--muted);display:inline-flex;align-items:center;gap:7px;font-weight:600}
#sort{border:1px solid var(--border-2);background:var(--surface);color:var(--text);
  border-radius:9px;padding:7px 10px;font-size:13.5px;font-weight:600;cursor:pointer}
#sort:focus{outline:none;border-color:var(--brand)}
.result-bar{margin-top:12px;font-size:13px;color:var(--faint);font-weight:600}

/* ===== Results ===== */
.cat-group{margin:0 0 30px}
.cat-head{display:flex;align-items:center;gap:11px;margin:0 0 14px;padding-bottom:9px;border-bottom:2px solid var(--catc,var(--brand))}
.cat-head .cat-name{font-size:18px;font-weight:780;letter-spacing:-.2px}
.cat-head .cat-bar{width:5px;height:22px;border-radius:3px;background:var(--catc,var(--brand))}
.cat-head .cat-n{margin-left:auto;font-size:12.5px;font-weight:700;color:#fff;background:var(--catc,var(--brand));
  padding:3px 11px;border-radius:999px}
.cat-head.core .cat-name::after{content:"核心";font-size:11px;font-weight:700;color:var(--core);
  background:var(--core-soft);padding:2px 8px;border-radius:6px;margin-left:9px;vertical-align:2px}

.grid{display:grid;gap:14px}
.paper{
  background:var(--surface);border:1px solid var(--border);border-left:4px solid var(--catc,var(--brand));
  border-radius:12px;padding:17px 19px;box-shadow:var(--shadow);transition:transform .1s ease,box-shadow .1s ease;
}
.paper:hover{transform:translateY(-1px);box-shadow:0 2px 4px rgba(16,40,46,.06),0 14px 32px -16px rgba(16,40,46,.3)}
.paper .ttl{font-size:16px;font-weight:700;line-height:1.4;margin:0 0 7px}
.paper .ttl a{color:var(--text);text-decoration:none}
.paper .ttl a:hover{color:var(--link);text-decoration:underline;text-underline-offset:3px}
.paper .pmeta{font-size:13px;color:var(--muted);margin:0 0 9px;display:flex;flex-wrap:wrap;gap:5px 9px;align-items:center}
.paper .pmeta .au{font-weight:600;color:var(--text)}
.paper .pmeta .jr{font-style:italic}
.paper .pmeta .yr{font-weight:700;color:var(--brand-2)}
.paper .pmeta .sep{color:var(--faint)}
.paper .badges{display:flex;flex-wrap:wrap;gap:7px;margin:0 0 10px}
.badge{font-size:11.5px;font-weight:700;padding:3px 9px;border-radius:7px;letter-spacing:.01em;white-space:nowrap}
.badge.type{background:var(--surface-3);color:var(--muted)}
.badge.trial{background:var(--brand-soft);color:var(--brand-2)}
.paper .find{font-size:14.5px;color:var(--text);margin:0 0 11px;line-height:1.6}
.paper .src{display:inline-flex;align-items:center;gap:6px;font-size:12.5px;font-weight:700;
  color:var(--link);text-decoration:none;border:1px solid var(--border-2);border-radius:8px;padding:4px 11px}
.paper .src:hover{background:var(--brand-soft);border-color:var(--brand)}
.paper .src svg{width:13px;height:13px;fill:none;stroke:currentColor;stroke-width:2}

.empty{text-align:center;color:var(--muted);padding:50px 20px;font-size:15px}
.hidden{display:none}
mark{background:rgba(45,212,191,.32);color:inherit;border-radius:3px;padding:0 1px}

/* ===== Footer ===== */
footer{border-top:1px solid var(--border);background:var(--surface);padding:26px 0;margin-top:20px}
.foot-inner{font-size:13px;color:var(--muted)}
.foot-inner>div:first-child{font-weight:700;color:var(--text);margin-bottom:6px}
.foot-note{font-size:12.5px;color:var(--faint);max-width:760px}

@media (max-width:640px){
  .hero{padding:46px 0 34px}
  .card{padding:20px 17px}
  .filter-row{flex-direction:column;align-items:stretch}
  .control-right{justify-content:flex-end}
  .paper{padding:15px 15px}
}